Hardwired Physiological Outliers & Poly-eXtremophiles


“Time is the school in which we learn, Time is the fire in which we burn.”

– Delmore Schwartz, Summer Knowledge (1959)

We're presently focused on those types of rare human beings that possess latent, rather critter-like, phenomenal powers of metabolic flexibility & that flaunt life's metabolic flame &, thus, biological time. That is, a latent metabolic ability to go from a raging fire to a dimmer of a pilot-light &, vitally, without getting burned or blowing themselves out in the process. These high-end metabolic machines are a unique, data-rich source of biomedical interest & worth.


"I love those that know not how to live except as down-goers, for they are the over-goers. ” – Friedrich W. Nietzsche, Thus Spoke Zarathustra (1883)

Stapp's omnipresent law, "the universal aptitude for ineptitude makes any human accomplishment an incredible miracle",  constrains us to experimenting with eXtremophiles, i.e., individuals hardwired to explore the boundary, the edge, & with a penchant for pushing back the envelope of existence. These, no catalyst needed, self-actuated types are already preconditioned (programed) & putting real deal, not make-believe, skin-in-the-game. We're not talking about daredevils but rather seldom miss a step or over-step the mark types that have a profound understanding of the risk-reward equation. Because they do play hard & have a high "get it factor", they've developed a deeper, more heightened & finely-tuned sense of observation & awareness. They are a unique source of biofeedback.

Incoriggible Mavericks

"At some point, you have to make a decision. Boundaries don't keep other people out, they fence you in. Life is messy, that’s how we're made. So, you can either waste your life drawing lines or you can cross them." – Meredith Grey (2006)

We're most interested in persons that can't help but cross lines, but without over-stepping them, i.e., questioning & contrarian types, black sheep, free-thinkers, rule-breakers, but not unethical law-breakers. Basically, individuals with gravitas who prefer & don't fear flying solo. Our reasoning, such types possess unique takes on the world that differ from the traditional or authorized narratives, & we believe they are key to making radical, transformative, advances that may lead to new worlds of possibilities & opportunities.